What’s Totally different In regards to the Johnson & Johnson COVID Vaccine?


health care worker filling a vaccine syringe

Photograph: Guillermo Legaria (Getty Pictures)

Johnson & Johnson released numbers today from their phase 3 medical trials (the final step earlier than making use of for emergency use authorization) and it appears like we might quickly have a 3rd viable COVID-19 vaccine within the US.

This vaccine is a bit totally different from the opposite two. Those from Pfizer/BioNTech and Moderna are each mRNA vaccines, which require two doses and have to be saved at freezer temperatures or in particular ultra-chilly packaging. The Johnson & Johnson vaccine could be saved at fridge temperature, like most any different vaccine you’d get at a pharmacy or physician’s workplace. And it solely requires one dose.

The brand new vaccine was discovered to be 85% efficient in stopping extreme COVID-19 illness, the press launch stated, and within the U.S., it was 72% efficient at stopping “average to extreme” illness. In different international locations, the effectiveness gave the impression to be decrease, all the way down to 56% efficacy in South Africa, the place the commonest COVID pressure is a concerning variant. It’s not clear but whether or not the distinction is because of the variant or to another issue or mixture of things.

When you’re questioning concerning the distinction between “average” and “extreme” COVID-19, the press launch included these definitions:

Within the research, the definition of extreme COVID-19 illness included laboratory-confirmed SARS-CoV-2 and a number of of the next: indicators in step with extreme systemic sickness, admission to an intensive care unit, respiratory failure, shock, organ failure or demise, amongst different elements. Average COVID-19 illness was outlined as laboratory-confirmed SARS-CoV-2 and a number of of the next: proof of pneumonia, deep vein thrombosis, shortness of breath or irregular blood oxygen saturation above 93%, irregular respiratory price (≥20); or two or extra systemic signs suggestive of COVID-19.

Amongst individuals who acquired the vaccine, no person skilled any hospitalizations or deaths from COVID as soon as they had been 28 days out from their first and solely dose.

Even when this vaccine seems to be much less efficient general than the mRNA vaccines, the actual fact that it solely requires one dose and could be distributed at fridge temperature might imply it will probably attain extra folks—and attain them extra shortly—than these vaccines.



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